Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice.

Cell Death Differ · 2012 · PMC3260394 · PMID 21997189

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did not reach statistical significanceP =0.0623so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

Although vehicle-treated p53 +/− mice showed a trend towards increased survival compared with ABT-737-treated p53 +/− animals (median survival: vehicle=469 days versus ABT-737=312 days), this difference did not reach statistical significance ( P =0.0623).

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