Indicators of the atherogenic lipoprotein phenotype measured with density gradient ultracentrifugation predict changes in carotid intima-media thickness in men and women.

Univariate analyses for CIMT progression as an ordinal (tertile) variable yielded a significant trend for increasing CIMT progression tertile with greater concentrations of fasting glucose ( P = 0.006) and a significant trend for less CIMT progression higher baseline CIMT ( P < 0.001).

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Statistically significant and near-significant predictors of the posterior wall CIMT progression rate included LDL peak time ( P = 0.045), HDL-C ( P = 0.001), HDL 2 -C ( P = 0.005), HDL 3 -C ( P = 0.003), VLDL-C ( P = 0.037), VLDL 1+2 -C ( P = 0.016), VLDL 3 -C ( P = 0.056), and TG ( P = 0.079).

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