Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis.

When we compared the three groups based on the K/L score, only SOD2 showed a significant trend towards proportionally higher serum levels in both groups B (K/L grade II and III) and C (K/L grade IV) than in group A (K/L grade 0 and I) (p < 0.001) (Table 3 ).

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The results obtained in this work showed that SOD2 was significantly increased in OA patients, even those OA patients with higher radiographic grade showed the highest values too; meanwhile catalase showed a trend toward higher levels in the OA group, but did not reach the statistical significance.

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