Recently De Backer and coworkers [ 207 ] in a multicenter and randomized trial involving 1679 patients in a state of shock, compared the results of treatment with dopamine or norepinephrine and found that patients who were treated with dopamine had higher 28 days- mortality (52.8%) than those treated with norepinephrine (48.5%), but it did not reach statistical significance (p = 0.10).
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In a retrospective study of 83 septic patients, of whom only were previously treated with beta-blockers 23, the authors didn ́t show a significant association between beta blockers and increased mortality in septic patients [ 244 ], but the overall mortality was 10% higher in the group exposed to beta-blockers, although this difference was not statistically significant, it showed a trend toward worse outcome.