Interferon-alpha administration enhances CD8+ T cell activation in HIV infection.

Interferon therapy tended to increase the proportion of Ki-67+ cells in central memory CD4+ T cells from 1.1% at baseline to 2.4% at week 3 (p = 0.176) and 1.9% at week 12 (p = 0.091, ( Figure 4 ), although these trends failed to reach statistical significance.

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We also saw a tendency for CD4+ central memory T cells to enter cell cycle during interferon therapy, although this trend did not reach statistical significance.

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