While there was a trend for greater levels of TNF and IL-1 in LPS treated CUS mice (compared to CUS-vehicle), this did not reach statistical significance (p = 0.07).
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Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge.
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0.0700
0.0700
The sentences
A similar trend for an increase in basal expression of TNF (hippocampus) and IL-1 (midbrain and hippocampus) mRNA was also observed in PS mice, although this effect failed to reach statistical significance.