Rosiglitazone Fails to Improve Renal Function Significantly in Moderate I/R Injury In an in vivo model of renal I/R injury caused by an ischemic period of 45 min, treatment with rosiglitazone showed a trend towards improvement of renal functional parameters (GFR, RPF) but failed to reach statistical significance (data not shown).
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Rosiglitazone affects nitric oxide synthases and improves renal outcome in a rat model of severe ischemia/reperfusion injury.
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