A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin.

There was a trend for a negative correlation between prechallenge cultured ELISPOT responses against the same antigens (which measures central memory T-cell responses [ 16 ]) and CFU count after challenge, although this did not reach statistical significance ( R = −0.4; P = .2) ( Figure 3 C ).

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Data from this clinical study showed a trend for prechallenge cultured ELISPOT responses to negatively correlate with CFU count after challenge, although this did not reach statistical significance.

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