The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

Although the effect size was very similar in the Thai population (β = −3.044) the findings did not reach statistical significance due to the reduced MAF (0.056 vs. 0.428 in the European ancestry cohort) of rs6954897 and smaller sample size in the Thai population.

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We arbitrarily selected p<5.0×10 −4 as nominally significant since it corresponds to a corrected p-value of 0.05 after correction for 100 independent gene regions and the 508 SNPs analyzed in the study fell into ∼100 independent linkage disequilibrium blocks.

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