Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination.

PLoS One · 2012 · PMC3319553 · PMID 22496775

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showed a trendno p-value reported

placebo controls and also showed a trend towards increased HIV infection after vaccination in uncircumcised men with pre-existing Ad5 neutralizing antibodies [1] , [2] .

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did not reach statistical significanceno p-value reported

A trend towards increased HIV infection frequency was observed in vaccinated subpopulations, though it did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.