α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.

PLoS One · 2012 · PMC3352914 · PMID 22615757

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a strong trendno p-value reported

Our data also suggest a contribution to increased risk by the G-allele for rs356165 (OR 1.66; 95%CI:0.96–2.88), and we observed a strong trend across categories when both genetic variants were considered (p for trend = 0.002).

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did not reach statistical significanceno p-value reported

Separately, the G allele of SNCA rs356165 increased risk of faster progression 60% (one copy) or 270% (two copies) under an additive genetic model ( table 6 ), albeit this association did not reach statistical significance.

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