Importantly, our method could effectively reject many marginally significant pathways detected by standard methods, including several long-gene-based, cancer-unrelated pathways.
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Personalized pathway enrichment map of putative cancer genes from next generation sequencing data.
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Investigation of the MutGenes in this type did not show a strong trend toward any gene(s) substantially contributing to the crosstalk events as observed in the clique-group.
We selected pathways that were co-mutated in 2 or more samples, and had a co-occurrence P value that was nominally significant.