Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Although myriocin treatment improved myocardial glucose utilization in DIO mice, we observed a slight increase in H + production in hearts from myriocin treated DIO mice, however this did not reach statistical significance.

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Diet-induced Obesity and Insulin Resistance Reduce Myocardial Glycolysis Rates, Which are Restored by Myriocin Treatment Aerobic perfusion of hearts following DIO showed a marked reduction in myocardial glycolysis rates, and a strong trend towards a reduction in glucose oxidation rates ( Figure 2 ).

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Interestingly, we observed a small trend to an increased H + production from uncoupled glucose metabolism in hearts from DIO mice treated with myriocin ( Figure 4 ).

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