Approximately one third of the peaks that had remained only marginally significant (= significant at a lower threshold of 10% FDR) in the standard analysis, were now detected as significant at 5% FDR after VBQTL analysis, likely due to the negative effect of confounding sources on power in the original approach.
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Expression variation in connected recombinant populations of Arabidopsis thaliana highlights distinct transcriptome architectures.
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The sentences
Our result agrees with another study in Mouse, where many highly significant local-eQTLs and moderately significant trans -acting associations were observed [ 29 ].