Investigational Paradigms in Downscoring and Upscoring DCIS: Surgical Management Review.

The relative risk of developing an LR stratified by surgical margins was plotted as a continuous variable with a clear trend on decreasing the hazard ratio for local failure [ 43 ].

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With margins 1–9 mm (score 2), there was a significant trend toward a benefit from irradiation.

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With margins less than 1 mm (score 3), there was a highly significant decrease in the probability of LR if radiation therapy was added [ 24 ].

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