Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.

There was a tendency towards a shorter disease duration in the group with a C9ORF72 repeat expansion, though this did not reach statistical significance (p = 0.08).

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Cases with a rapid progression of disease showed more extensive microglial pathology as illustrated by CD68 IHC results in most of the regions analyzed here (p<0.05 each, Figure 3 ), with the exception of the CSC and motor cortex white matter, where the difference failed to reach statistical significance.

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