Chromosome instability and benefit from adjuvant anthracyclines in breast cancer.

Br J Cancer · 2012 · PMC3389422 · PMID 22644297

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a strong trendP =0.054so close (0.05 < p ≤ 0.1)

did not reach statistical significanceP =0.054so close (0.05 < p ≤ 0.1)

In multivariate analysis, high tumour CIN% was not an independent predictor for RFS (HR: 1.28, 95% CI: 0.74–2.209) but for OS there was a strong trend that did not reach statistical significance (HR: 1.76, 95% CI: 0.99–3.13, P =0.054).

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a trend towards significanceno p-value reported

In this study, we have shown a trend towards significance for an increased benefit from the addition of anthracycline in patients with high CIN.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.