As regards TGFβ1 serum levels, a negative trend was observed at stages II and III adenocarcinomas, with a significant difference only at stage III ( Figure 3A ).
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Progressive increase of matrix metalloprotease-9 and interleukin-8 serum levels during carcinogenic process in human colorectal tract.
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the most commonly used inflammatory marker, showed a trend quite similar to that of IL-8, with normal serum levels in patients with benign colorectal tumors, and an increase starting from stage II of malignancy, but just below statistical significance ( Figure 2 ).