Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression.

Changes in lymphocytes and total CD4+ T cells at 1 month and 3 months after transplantation As shown in Figure 1 , Figure 2 , there was a decrease in the percentage of lymphocytes after transplantation (1 month: 60.0±15.3%; 3 months: 64.1±13.6%) compared with before transplantation (70.5±15.0%), but this did not reach statistical significance ( P >0.05) ( Figure 2A ).

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The expression of HMGB1 mRNA also showed a trend to increase at 1 month (1.2±0.8) and 3 months (1.3±0.7) after transplantation compared with before transplant (1.1±0.5) (at 1 month P = 0.60; at 3 months, P = 0.36) ( Figure 4B ).

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