Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.

Also, the TcpF-A2-CTB chimera immunization group did not have as high a survival rate as the CTB only immunization group (50% versus 67%; Table 1 ), although this difference did not reach statistical significance ( P >0.05).

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However, immunization with TcpF+CTB was highly protective and showed a trend toward greater protection than immunization with CTB alone (82% vs 64% survival).

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