Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease.

J Neuroinflammation · 2012 · PMC3416679 · PMID 22642812

Europe PMC DOI

hedged sentences

0.2100

closest p · 4.2× alpha

0.2100

boldest claim

The sentences

did not reach statistical significanceP > 0.21not close (p > 0.1)

Insoluble Aβ40 and Aβ42 levels were also elevated but did not reach statistical significance ( P > 0.21; Figure 2 C and D).

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failed to reach statistical significanceno p-value reported

Mean GFAP immunopositive area for astrocyte reactivity was lower in hIVIG treated mice than in the saline group, but failed to reach statistical significance.

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may be significantno p-value reported

Nevertheless, even the longer hIVIG treatment did not reduce amyloid deposition but induced selective immunomodulation and enhanced neurogenesis, which both may be significant for the beneficial clinical effects of hIVIG in AD patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.