Foxp4 is dispensable for T cell development, but required for robust recall responses.

A similar trend toward lower IFNγ was seen when comparing Cre NEG to cHET and cHET to cKO cells, but the difference did not reach statistical significance.

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Given that effector function of Foxp4 cKO splenocytes showed a trend toward decreased response to STAg stimulation, we also asked whether the functionality of T cells in the brain, a site at which constant antigen presentation occurs during toxoplasmosis, was altered.

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