Immune senescence: relative contributions of age and cytomegalovirus infection.

As expected, LCMV control was affected by age, since LCMV titres were between 3- and 6-fold higher in old compared to young mice although the difference did not reach statistical significance ( p = not significant (ns) ; Figure 1A, B ).

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In addition, old Tx mice with latent MCMV infection showed a trend to even higher LCMV titres in all tested organs (2- to 9-fold, p = ns ) and thus to reduced protective immunity compared to old Tx mice.

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M45-specific cells were stably maintained at low levels well into senescence with a slight trend for increasing numbers at very old age ( Figure 2D, F ) suggesting that these cells and their naïve precursors were not exhausted.

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Overall, the effects of MCMV-infection on the CD4-compartment were much more subtle but similar to CD8 as an overall trend, whereas Tx had a more profound and immediate impact on the total and the naïve CD4 compartment.

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