Subjects with MCI (CDR 0.5, n = 20) showed a trend toward higher levels than controls (CDR 0, n = 18), but the trend did not reach statistical significance. p3-Alc α levels in subjects with mild AD (CDR 1, n = 13) were significantly higher than those in controls ( p < 0.05; Tukey-Kramer’s multiple comparison test).
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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
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The sentences
Subjects with MCI (CDR 0.5, n = 20) showed a trend toward higher levels than controls (CDR 0, n = 18), but the trend did not reach statistical significance. p3-Alc α levels in subjects with mild AD (CDR 1, n = 13) were significantly higher than those in controls ( p < 0.05; Tukey-Kramer’s multiple comparison test).