showed a trendp = 0.08
Intra-articular glucocorticoids showed a trend towards reduced 15-PGDH expression in RA synovium (p = 0.08) while methotrexate treatment left the PGE 2 pathway unaltered both in biopsies ex vivo and in cultured FLS.
Intra-articular glucocorticoids showed a trend towards reduced 15-PGDH expression in RA synovium (p = 0.08) while methotrexate treatment left the PGE 2 pathway unaltered both in biopsies ex vivo and in cultured FLS.
Overall, although no statistical difference ( P = 0.08) was detected before or after local GC injection, there was a clear trend toward diminished enzyme expression following therapy.