Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance.

Arthritis Res Ther · 2012 · PMC3446525 · PMID 22691272

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a strong trendno p-value reported

did not reach statistical significanceno p-value reported

To test this hypothesis, DLNCs from the mice treated with mianserin showed a significant decrease in anti-CD3-induced IL-17 production; a strong trend toward lower production of antigen-specific IFNγ and IL-17 was observed, although this did not reach statistical significance (Figure 2f ).

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