Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro.

2B, 2D ) where there was no surgical injury, but with borderline significance at sites of carotid cuff compression injury (N = 11, p = 0.06, Fig. 2E ), when compared to saline ( Fig. 2A, 2D ).

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1C : 0.3 ng/p = 0.377; 30 ng/p = 0.138 and 3000 ng/p = 0.567) or D294A (6 rats/dose; N = 18; 0.3 ng/p = 0.821; 30 ng/p = 0.076 and 3000 ng/p = 0.623, not shown) showed a trend toward reduced plaque at the 30 ng dose, but failed to inhibit plaque growth at higher concentrations.

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In our model, 4 weeks post-transplantation, saline treated ApoE −/− GzmB −/− DKO allografts had a significant trend toward reduced plaque area ( Fig. 6A ) and IMT ( Fig. 6B ) when compared to saline treated ApoE −/− allografts ( Fig. 6A ), suggesting that GzmB deficiency in donors has variable effects on plaque growth.

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