Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health.

AfA, HA and AsA adolescents We observed directionally consistent effect estimates in AfA (25 SNPs), HA (30 SNPs) and AsA (24 SNPs) adolescents relative to published results from European-descent populations, with greater than expected number of nominally significant SNP associations in AfA (eight), marginal significance in AsA (five), but not HA (three) based on a binomial draw at P <0.05 ( Figure 2 , Table 2 , and Supplementary Table 1 ).

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Four SNPs, rs887912 (near FANCL ), rs1514175 (near TNNI3K ), rs713586 (near POMC ) and rs9939609 (near FTO ), showed a trend ( P <0.1) for larger effect sizes in adolescents compared with adults, but none showed a trend for larger effect sizes in adults compared with adolescents.

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Of 41 BMI–SNP associations in AfA, HA and AsA adolescents, nine, three and five, respectively, were directionally consistent and nominally significant.

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