5 F and G ), although this did not reach statistical significance ( P = 0.059).
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Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.
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Morphometric analysis of pancreatic sections from VEGF low mice showed a trend toward decreased β-cell mass only at the age of 12 months ( Fig. 5 F and G ), although this did not reach statistical significance ( P = 0.059).