Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction.

PLoS One · 2012 · PMC3482221 · PMID 23110086

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0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

showed a trendp <0.1so close (0.05 < p ≤ 0.1)

However, the subspecies distribution showed a trend for higher C18, C20, C22, C24:1 and C24 in the aged fractions ( p <0.1) ( Fig.

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did not reach statistical significanceno p-value reported

Although the difference between Cer amounts in young and old CD4 + T cells did not reach statistical significance, there was a similar trend towards elevated quantities with age: Cer levels in young CD4 + T cell non-IS fractions were 34.8±1.8 pmol versus 64.8±17 pmol for the old group, a trend toward increase with age (mean ± SEM, p <0.1) ( Fig. 2A ).

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