Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding.

Front Hum Neurosci · 2012 · PMC3483622 · PMID 23115550

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did not reach statistical significanceno p-value reported

FMRP was reduced by 23% in the FXPC group relative to controls (FXPCs: mean = 77.08, SD = 67.15; Controls: mean = 100.38, SD = 56.90); however this difference did not reach statistical significance, possibly as a result of high variability within both groups.

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approached significanceno p-value reported

There was a negative correlation between mRNA and FMRP measures that approached significance ( r = −0.427, p = −0.099).To test the effects of these molecular measures on brain activations, a correlation analysis was run between the BOLD signal from regions associated with encoding and all molecular measures.

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