GluN1 hypomorph mice exhibit wide-ranging behavioral alterations.

Pairwise comparisons showed this to be due to GluN1 hypo female mice exploring more than WT female mice (WT 21.0 ± 3.3 s, GluN1 hypo 47.0 ± 7.2 s; P < 0.001), WT male mice (25.0 ± 2.4 s, P = 0.002) and showed a trend toward exploring more than GluN1 hypo male mice (31.5 ± 3.5 s, P = 0.064).

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However, genotype effects on time spent in the light area were not seen when started in the dark (WT 4.6 ± 1.8 s, GluN1 hypo 34.0 ± 15.4 s; F 1,31 = 3.629, P = 0.066) although there was a strong trend for the GluN1 hypo mice to once again spend more time in the light area.

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