Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.

AAV9-mTERT treated mice also showed a trend for an improved glucose uptake and a better homeostatic model assessment (HOMA (Heikkinen et al, 2007 ; Matthews et al, 1985 )) compared to the AAV9-eGFP controls, although differences did not reach statistical significance (Supporting Information Fig S4D and E ).

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The subgroup of AAV9-mTERT treated mice that maintained or decreased the percentage of short telomeres also showed an apparent trend to survive longer than those that increased percentage of short telomeres, in both age groups (Supporting Information Fig S7F ), suggesting that rescue of short telomeres is associated with increased longevity.

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