Soluble KIT correlates with clinical outcome in patients with metastatic breast cancer treated with sunitinib.

Greater sKIT change (either as a categorical or continuous variable) and age < 65 (noting that this group represented 98% of patients) were significantly associated with improved OS in the multivariate analyses (p = 0.0085, < 0.0001, and = 0.0045, respectively), while greater VEGF-A change (categorical variable) and age evaluated as a continuous variable showed marginally significant associations (both p = 0.047).

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Greater increases in VEGF-A levels showed a trend towards an association with improved TTP and a statistically significant association with improved OS.

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In our analyses, it may be worth noting that there was a trend towards an association between low baseline VEGF-A levels and improved outcomes (Tables 2 and 3 ), although this did not reach statistical significance.

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