Interestingly, midbrain dopaminergic neurons that had been subjected to MPP + only showed a trend of reduced neurite length (79.7 ± 9.5%) whereas 20 μM fasudil still maintained a larger neurite length with MPP + (110.8 ± 8.2%) compared with the MPP + control ( Fig. 2 A and C).
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Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
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The sentences
This effect was significant in the fasudil group and showed a strong trend after application of Y-27632.