Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.

Immunostaining of the sh tumors showed a trend toward an increase in P-ERK in the shR2 tumors and a decrease in the PD173074 tumors in comparison to the LacZ controls; however, due to tumor tissue heterogeneity, the overall differences in tumors were difficult to evaluate (data not shown).

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Tumor growth was inhibited by PD173074 but due to a variation of growth stimulation of shR2 tumors, the difference did not reach statistical significance ( Figure 3B ).

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