Natalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis.

PLoS One · 2012 · PMC3527399 · PMID 23284936

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did not reach statistical significanceno p-value reported

Due to inter-individual variability, however, it did not reach statistical significance in the cohort as a whole when each of the individual cytokines was evaluated.

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showed a trendno p-value reported

Surprisingly, natalizumab induced a modest reduction of MMP-2 secretion, as did CD3/28 costimulation in a synergistic manner (p<0.05), and it showed a trend towards a reduction of MMP-9 protein secretion, which in contrast to MMP-2 was strongly induced by CD3/28.

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