Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects.

PLoS One · 2013 · PMC3547044 · PMID 23342035

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highly significantno p-value reported

Additionally, a highly significant relationship between aromatase SNPs and circulating estrogen levels among postmenopausal women has been found by Haiman et al.

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showed a trendno p-value reported

showed a trend to association with breast cancer risk in BRCA1 carriers aged <50 years [26] .

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did not reach statistical significanceno p-value reported

Though some of these cases-control studies did not reach statistical significance, it is possible that the polymorphism contributed to levels of circulating sex hormones.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.