Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.

Of notice, TgTERT mice under the control diet performed better than WT mice under the same diet, although the differences did not reach statistical significance ( Fig. 1J ; p = 0.08 ) , in line with an improved health status and delayed aging associated to TERT over-expression [25] .

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1F ) showed a trend to be lower in CR WT mice, and this trend reached statistical significance in TgTERT mice after 12 months of CR diet compared to the corresponding cohorts under a control diet ( Fig. 1F ; p = 0.006 ) .

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