Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.

[16] identified 8 additional GSV loci with nominally significant association with obesity, on the basis of being present in children with “common” obesity (individuals with severe obesity were excluded from the study) but absent from control cohorts of normal weight.

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We also attempted replication using BMI as a quantitative trait in our population cohort; associations with BMI at or near nominal significance were detected at two further loci near KIF2B and within FOXP2 , but these did not survive correction for multiple testing.

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