“near nominal significance”

Among NHW COPD participants from SPIROMICS, the BAIAP2 gene was also associated with weight loss at a level near nominal significance ( P = 0.055) contributing to the significant meta‐analysis result ( P = 5.20 × 10 −7 ).

In the three European American cohorts, rs12526480 was statistically significant in one cohort (p = 0.01) and near nominal significance in the combined meta-analysis (p = 0.06) with an effect size and direction similar to that observed in African Americans.

Note that the comparison of FF and NP was near nominal significance for speed [ t (10) = 2.085; p = 0.064].

We also attempted replication using BMI as a quantitative trait in our population cohort; associations with BMI at or near nominal significance were detected at two further loci near KIF2B and within FOXP2 , but these did not survive correction for multiple testing.