Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.

PLoS One · 2013 · PMC3596339 · PMID 23516558

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.0740

boldest claim

The sentences

marginally significantp = 0.074so close (0.05 < p ≤ 0.1)

This association remains marginally significant after Bonferroni correction for multiple testing (Bonferroni-corrected p = 0.074).

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did not reach statistical significanceno p-value reported

Numerous factors may have contributed to the lack of replication of most results between these studies, including the fact that the earlier GWAS results did not reach statistical significance, and perhaps do not represent true associations.

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nominally significantno p-value reported

The follow-up study included 121 SNPs that produced p-values <10 −4 in the GWAS, as well as 19 nominally significant SNPs from genes of which homologs had shown expression changes in rat brains in response to alcohol consumption.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.