Effect of HSu treatment on redox status markers Both serum and heart tissue lipid peroxidation showed a trend for an increase, although the levels did not achieve statistical significance (Figure 4 A and B).
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Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.
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The sentences
Regarding the impact of the HSu diet on the cardiac tissue, our results indicated that 9 weeks of treatment might be associated with initial cardiac changes, as suggested by the increased LV weight/BW ratio (P < 0.01) and a remarkable brain natriuretic peptide (BNP) mRNA overexpression (P < 0.01), together with a marked trend for an upregulation of other important mediators of fibrosis, hypertrophy, angiogenesis and endothelial lesions, as well as oxidative stress.