Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.

Further analysis revealed a trend toward a greater number of apical dendrites in NSE-apoE3 mice than in NSE-apoE4 mice in the CA1, although this difference did not reach statistical significance ( Fig. 1C ).

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NSE-apoE4 mice showed a trend toward decreased total dendrite length in the CA1 ( Fig. 1D ) compared to NSE-apoE3 mice, and basal NSE-apoE4 dendrites were significantly shorter than basal NSE-apoE3 dendrites ( Fig. 1E ).

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