PD184352 treatment decreased the induction IL-10 mRNA by zymosan, while SB203580 showed a trend for a reduction in IL-10 mRNA although this did not reach statistical significance (p<0.05).
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Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.
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The sentences
PD184352 treatment decreased the induction IL-10 mRNA by zymosan, while SB203580 showed a trend for a reduction in IL-10 mRNA although this did not reach statistical significance (p<0.05).