Evaluating purifying selection in the mitochondrial DNA of various mammalian species.

None of the analyzed data definitively rejected the molecular clock ( Table 1 ), though the Sus data p-value was close to significance.

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The average ρ was statistically significantly lower for the class with higher pathogenicity score in all species (except for Sus , where the difference did not reach statistical significance due to the high standard errors; Figure 1A ).

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The Mus and Sus data significantly support the use of a more complex model of nucleotide evolution while others are borderline non-significant ( Orcinus and Canis ).

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