Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort.

PLoS One · 2013 · PMC3618421 · PMID 23577133

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0800

boldest claim

The sentences

showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

Once amplified cases were segregated from other cases of gene gain, non-amplified gene increases ( TOP1 /CEN-2≥1.5 and TOP1/CEN-20<2.0) showed a trend towards shorter TTR (univariate HR: 1.57, p = 0.07).

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approached significancep = 0.08so close (0.05 < p ≤ 0.1)

Amplification of TOP1 was not significantly associated with OS or TTR, although approached significance for TTR in the multivariate analysis (HR: 0.50, 95% CI: 0.23–1.09, p = 0.08).

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a weak trendno p-value reported

Amplification of the TOP1 gene, representing a situation where CEN-20 is not involved in gene gain, exhibited a weak trend towards longer TTR when compared to the rest of the population, a finding which may be attributed to the low number of event in this particular subgroup.

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