A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.

MYO10 expression correlated negatively with plasma levels of adiponectin (although this did not reach statistical significance) and was positively correlated with plasma leptin at Summary of candidate gene prioritization Table 5 summarizes all the biologically relevant cancer or pro-inflammation genes, annotated by the SNP associations and gene expression correlations with MetS phenotypes under the adiponectin QTL peaks of 5p14 and 14q13.

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SNPs that passed region-specific significance thresholds for respective traits and/or the highest nominally significant SNP of each trait for each trait are shown in Tables 2 and 3 .

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This study identified two highly significant quantitative trait loci (QTLs) on chr5p14 and chr14q13 [ 10 ].

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Two of these associations (TG and TC) were borderline significant, marginally reaching the regional threshold (Table 3 and Figure 2 A).

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