Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease.

After adjusting for traditional risk factors such as HDL and medication use including angiotensin‐converting enzyme inhibitors, angiotensin II receptor blockers, β‐blockers, and statin therapy, lower serum arylesterase still conferred an increased risk of major adverse cardiac events at 3 years (hazard ratio 1.55, 95% CI 1.08 to 2.23, P <0.05), whereas PON activity displayed similar trends but again failed to reach statistical significance (hazard ratio 1.22, 95% CI 0.87 to 1.71, P =NS).

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Lower serum PON activity showed similar trends when divided by optimal cutoff [<280 nmol(L·min) per mL] but did not reach statistical significance (hazard ratio 1.35, 95% CI 0.98 to 1.88, P =NS; Table 2 ).

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