SKP2 high expression, KIT exon 11 deletions, and gastrointestinal bleeding as predictors of poor prognosis in primary gastrointestinal stromal tumors.

Besides mitotic index, tumor size and site, SKP2 high expression (RR = 2.91, 95% CI: 1.41–5.99, P = 0.004) and KIT exon 11 deletion (RR = 2.73, 95% CI: 1.04–7.16, P = 0.041) were also independent risk factors in multivariate analysis, with gastrointestinal bleeding also showing a trend towards significance (RR = 1.88, 95% CI: 0.98–3.64, P = 0.059).

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Although the P -value failed to reach statistical significance in models B and D, GI bleeding still showed obvious relative risk.

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In contrast, highSKP2 expression was a strong significant indicator in model B (RR = 2.91, 95% CI: 1.41–5.99), and GI bleeding was also valuable with near statistical significance (RR = 1.88, 95% CI: 0.98–3.64).

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